At a glance
In three years, Mozambique significantly improved TB Preventive Treatment (TPT) for people living with HIV (PLHIV), increasing coverage from 41% to 89%. This lifesaving intervention, supported by CDC and the Ministry of Health, is crucial for TB elimination and will help reduce TB cases and deaths in Mozambique and around the world.

The challenge of TB and HIV

In 2023, TB remained the leading cause of death among PLHIV, who are 16 times more likely to develop TB. When combined with HIV treatment, TPT can prevent TB disease and reduce TB deaths among PLHIV by 80%.
In Mozambique, both TB and HIV burdens are alarmingly high. This dual epidemic poses a significant threat to the U.S. and to global health security. Despite Mozambique’s introduction of TPT for PLHIV in 2007, only 40% had received a full course of treatment by March 2021. Recognizing this gap, CDC and partners rallied together to support the Government of Mozambique in implementing a comprehensive strategy to increase access to and completion of TPT, reducing TB transmission and improving health outcomes.
Innovative interventions drive success

From , CDC and partners adopted a comprehensive approach to increasing TPT coverage. This included training healthcare providers, strengthening data collection systems, and reinforcing the implementation of patient-centered services. These services included a short course of TPT and three-month medication dispensing, aligned with the dispensing of HIV medication. These initiatives improved screening and ensured that people could easily access and complete their treatment. The results speak volumes:
- Enrollment surge: The number of PLHIV enrolled increased by 35%, reaching over 1.6 million people.
- Coverage increase: TPT coverage skyrocketed from 42% to 89%, surpassing the national goal.
- Completion rates: Completion rates rose significantly from 81% to nearly 89%, reflecting improved treatment completion among children and adults.
- Healthcare Provider in Mozambique
CDC and partners continue to train healthcare staff on regular screening for TB symptoms, support the government in updating and implementing TB screening guidelines using the latest technology, and expand access to TPT nationwide.
- Alexandre Nguimfack, CDC Mozambique HIV Treatment Lead
Implications for global health security
Mozambique’s success contributes significantly to global health security. By reducing TB incidence among PLHIV – evidenced by a nearly 25% decrease – Mozambique is supporting the achievement of global TB elimination targets.
CDC’s involvement has been pivotal. Through partnerships with local governments and ministries of health around the world, over 9 million people globally have initiated and completed TPT. This collaboration saves countless lives and helps ensure that health threats, such as TB, do not cross borders.
A safer tomorrow
Ultimately, the fight against TB is more than just eliminating a disease; it is about building healthier societies that can thrive despite public health challenges. The results from Mozambique’s success with TPT serve as a reminder with determination, innovation, appropriate resources, and collaboration, significant advancements can be made toward achieving global health security.
Together, the U.S. and other countries have the power to transform lives through accessible and impactful healthcare solutions as they strive to eliminate TB in the U.S. and worldwide. By working closely across communities, sectors, and borders, CDC paves the way for a healthier future, free from TB and HIV, and a more prosperous world for generations to come.